Tissue distribution of exendin-4 in rats / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 95-101, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-407328
ABSTRACT
AIM To investigate the tissue distribution of exendin-4 after administration in healthy rats. METHODS Exendin-4 was radioiodinated by the Iodo-GenTMmethod. Tissue distribution of [125I]exendin-4 was investigated after sc administration of [125I]exendin-4 at 3 μg·kg-1 in rats. Both total radioactivity and trichloroacetic acid (TCA) precipitated radioactivity were used to calculate the levels of [125I]exendin-4 in rats plasma and tissue samples after sc administration. RESULTS The tissue distribution of [125I]exendin-4 after sc injection showed substantial disposition in kidneys, lungs, bladder and pancreas. The rank order of normalized tissue distribution was kidneys>lungs>bladder>pancreas>intestine>plasma>adrenals>jejunum>lymph>liver>spleen>heart>marrow>thymus>testicles>brain>muscle>adipose. CONCLUSION [125I]Exendin-4 underwent a rapid and wide distribution in the tissues throughout the whole body within the time course examined. TCA precipitated radioactivity in kidneys was the highest, however, only trace amounts of [125I]exendin-4 was detected in the brain.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Pharmacology and Toxicology
Année:
2008
Type:
Article
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