Induction of Labor with Oral Prostaglandin E2 or E1 Plus Oxytocin / 대한산부인과학회잡지

ABSTRACT

OBJECTIVE: Our purpose was to complete delivery during daytime through rapid and safe management with oral prostaglandin plus oxytocin, and to reduce the duration of induced labor, hospital stay and dispersion of human power. METHODS: Ninety pregnancies requiring induction of labor between December 1998 and July 1999 were analyzed prospectively. Patients were assigned to receive either oral PGE2 or oral PGE1. In one group, labor induction was performed with 0.5 mg of oral PGE2 (group 1, n=46), was orally taken every one hour since 0600 AM to 0900 AM and intravenous oxytocin infusion (The beginning dose was 2 mU/min, the dose increased by 2 mU/30 min) beginning at 0900 AM, and in the other group (group 2, n=44), 100 microgram of PGE1 was orally taken at 1100 PM the day before oxytocin infusion was commenced at 0700 AM. If there was uterine contraction of more than 200 Montevideo units, intravenous oxytocin would not be given. RESULTS: The mean time (+/-standard deviation) to active phase labor (cervical dilatation more than 3 cm and uterine contraction more than 200 Montevideo units) with PGE2 group was 335.16+/-157.89 minutes versus 534.16+/-211.79 minutes with PGE1 group (Por= 4, 0%) and the cesarean section rate was also (if or= 4, 19.4%) in the two groups (P<0.05). There were no clinical or statistical differences in demographic data, clinical characteristics, maternal outcomes and complications, and neonatal outcomes. CONCLUSION: Both may be proper methods of inducing delivery during daytime and begun at outpatient office base.