Changes of serum IL-10 in perioperative period in patients with hepatocellular carcinoma and its significance / 中华肝胆外科杂志

ABSTRACT

Objective　To determine the changes of serum IL-10 level in perioperative period in patients with hepatocellular carcinoma (HCC) and discuss its significance. Methods　The serum IL-10 level was determined with ELISA in 30 patients with HCC and 30 healthy volunteers. Results　The serum IL-10 level was significantly higher in the perioperative period in patients with HCC than in the healthy volunteers. In the patients with HCC, the level was higher before than after the operation. Meanwhile, it was markedly higher in patients with poorly differentiated tumor or the tumor with a diameter over 5 cm than in those with well-differentiated tumor or the tumor with a diameter less than 5 cm (P<0.01). Conclusion　HCC cells might produce IL-10 that may participate in immune response of HCC. Furthermore, IL-10 might be a factor that can reflect the differentiation grade, assess the prognosis and predict recurrence of HCC.