Advance in the establishment of four animal models for amyotrophic lateral sclerosis / 中国组织工程研究

ABSTRACT

OBJECTIVE: Amyotrophic lateral sclerosis(ALS) is a chronic progressive degenerative disease selectively infringing upper and lower motoneurons, and its pathogeny and pathogenesis are unclear till now. Its researches are mainly relying on animal models. Currently, there are many methods for the establishment of ALS animal.model and each of them has its own characters,practicability and values.DATA SOURCES Relative articles during the period from January 1980 to December 2003 were searched on the Medline database by the title of the article with the searching word "amyotrophic lateral sclerosis, model" and the language of the articles was limited to English.STUDY SELECTION Data were preliminarily screened for the selection of the literatures mainly regarding the researches of ALS animal models; and then literatures regarding the application of ALS animal model in medication effectiveness and pathogenesis were eliminated; the full texts of the rest literatures were searched as inclusive criteria.DATA EXTRACTION Totally 96articles searched with "amyotrophic lateral sclerosis, model" in title were collected. Fifteen tests were in accordance with the inclusive criteria. In the eliminated 81 tests, 75 literatures were about the researches on the application of ALS model for medication observation and pathogenesis research, and the rest 6 articles were repetitive experiments.DATA SYNTHESIS: ALS neurotoxic animal model, immune mediated animal model, spontaneous animal model, and transgenic animal model were established in the selected literatures, which also investigated the mechanism, features, practicability and value of the animal model.CONCLUSION: The establishment of animal models simulated ALS symptoms or pathogenesis in the above literatures can be used in ALS disease researches as referencing model, which could provide animal experimental basis for the researches of ALS pathogenesis and the confirmation of therapy plan.