Effects of ferulic acid on E-selectin expression in activated endothelial cell and leukocyte-endothelial cell adhesion / 药学学报
Acta Pharmaceutica Sinica
; (12): 410-413, 2005.
Article
de Zh
| WPRIM
| ID: wpr-409923
Bibliothèque responsable:
WPRO
ABSTRACT
Aim To study the effects of ferulic acid (FA) on E-selectin expression in human umbilical vein endothelial cells (HUVECs) activated by lipopolysaccharide and leukocyte-endothelial cell adhesion. Methods The effects of FA on E-selectin and E-selectin mRNA expression were determined by flow cytometry and reverse transcription polymerase chain reaction. The effect of FA on HL60-HUVEC adhesion was evaluated with the method of staining the cells by Rose Bengal. Results The expression of tively). Conclusion FA can inhibit the expression of E-selectin and E-selectin mRNA and HL60-HUVEC adhesion. This may contribute to its protective effect against ischemia-reperfusion injury.
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WPRIM
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2005
Type:
Article