99mTc-TRODAT-1 SPECT imaging of dopamine transporter in early diagnosis of Parkinsons disease / 中国神经精神疾病杂志
Chinese Journal of Nervous and Mental Diseases
; (12): 106-108, 2001.
Article
de Zh
| WPRIM
| ID: wpr-411411
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To evaluate the value of 99m Tc-TRODAT-1 SPECT DAT imaging in the early diagnosing of Parkinsons disease (PD).Methods Eleven patients (9 PD and 2 possible PD) and eighteen healthy subjects matched by sex and age were studied with 99m Tc-TRODAT-1 SPECT DAT imaging. Striatum specific uptake of 99mTc-TRODAT-1 was calculated according to the ratio of DAT uptake in striatum (ST) and cerebellum (CB). Results In the hemi-Parkinsons disease group, the DAT specific uptake of 99mTc-TRODAT-1 was significantly lower (P<0.01) in contralateral than in ipsilateral striatum to the clinically symptomatic side. There was significant decrease (p<0.01) of striatum DAT uptake in patients with hemi-PD compared to the controls.Conclusions 99mTc-TRODAT-1 SPECT DAT imaging may help to confirm the diagnosis of PD at the early stage.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Diagnostic_studies
/
Screening_studies
langue:
Zh
Texte intégral:
Chinese Journal of Nervous and Mental Diseases
Année:
2001
Type:
Article