Preparation and antioxidative activities of the sulfated Hunai polysaccharide / 中国生化药物杂志
Chinese Journal of Biochemical Pharmaceutics
;
(6): 1-4, 2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-412018
ABSTRACT
Purpose The aim is to sulfonize Hunai polysaccharide fr om p leurotus tuber-rigium(Fr.)Sing. and to evaluate the antioxidative activities of the sulfated po lysaccharide (S-HNP).Methods S-HNP was prepared by the reacti on of Hunai polysaccharide with chlorosulfonic acid-Pyridine. The antioxidative activities o f S-HNP were evaluated as follows (1) the inhibition effects on Fe2+- Vc inducing the injury of rat liver mitochondria in vitro, (2) the protectiv e ef fect on CuSO4 -Phen-Vc-H2O2 inducing the damage of DNA, (3) the scaven ging effect on O*-2. Results S-HNP could protect mitochondria from lipid peroxidation induced by Fe2+-Vc, i ncluding the inhibitions of the increase of TBARS content, the swelling of mitoc hondria and the decrease of membrane fluidity, and protect DNA from the damage induced by CuSO4-Phen-Vc-H2O2, and scavenge O*-2 generated in the sel f-oxidation of pyrogallic acid. Conclusion S-HNP exhibi ted marked antioxidative activities.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Biochemical Pharmaceutics
Année:
2001
Type:
Article
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