A Comparison between the Effects of Losartan and Fosinopril,Captopril on the Excretion Rate of Urinary Albumin and the Clearance of Endogenous Creatinine in Elderly Hypertensive Patients / 中国循环杂志

ABSTRACT

Objective:To evaluate the effects of losartan、fosinopril and captopril on the excretion rate of urinary albumin (UAER) and the clearance of endogenous creatinine (Cr-C) in elderly patients. 　　Methods:In this study,162 elderly patients with stage of the 2—3 class hypertension were included,The patients were divided into 3 groups,that were losartan group and the fosinopril group and captopril group,the anti-hypertensive effects and UAER and Cr-C were determined before and after the treatment. 　　Results:The hypertensive effect rates were 94% in losartan group and 93%、93% in fosinopril group and captopril group respectively.Decrease of UAER was observed in 89% of patient in losartan group and 59%、50% in fosinopril group、captopril group.Cr-C were improved in 94%、78% of patient in losartan group and in fosinopril group and 63% in captopril group. 　　Conclusions:Losartan has better effects on UAER and Cr-C than captopril in elderly hypertensive patients.