Localization Effect of 131 I-Human Anti-HBs Fab in Nude Mice Models of Human Hepatoma / 中国肿瘤生物治疗杂志
Chinese Journal of Cancer Biotherapy
;
(6): 288-290, 2000.
Article
Dans Chinois
| WPRIM
| ID: wpr-412394
ABSTRACT
Objective:
To evaluate the targeting activity in the animal model with human hepatoma, the 131I-human antiHBsAg Fab radioimmunoimaging was explored.Methods:
Radioimmunoimagings were taken on different intervals after injection of 131 I-human anti-HBsAg Fab to the nude mice and tissue distribution was measured. The human anti-HBsAg Fab was compared with the murine monoclonal antibodies.Results:
The experimental group developed tumor positive images after 3 days of radio-labeled monoclonal antibodies injection, and the peak accumulation of radio-activity on the 5th day.Statistics indicated the tumor/liver ratio of the human anti-HBsAg Fab, murine monoclonal antibodies and the control groups were 5.4,4.0 and 0.9 respectively on the 7th day.Conclusions:
Our results suggest that the 131 I-human anti-HB-sAg Fab has a considerable targeting activity, and provide an evidence that it can be used as a novel humanized carrer for targeting therapy of hepatoma.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Cancer Biotherapy
Année:
2000
Type:
Article
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