The clinical study of ginkgo-damole combined with prostaglandin E1 in treatment of diabetic patients with peripheral arterial disease / 中国基层医药

ABSTRACT

Objective To investigate the therapeutic effect of ginkgo-damole combined with prostaglandin E1 and explore its influences on clinical evaluation and hemorheology paramaters in treatment of diabetic patients with peripheral arterial disease(PAD). Methods 64 patients were randomly divided into two groups the therapeutic group was given conventional therapy adding ginkgo-damole combined with prostaglandin E1, while the control group was given ginkgo-damole only. To compare ankle-brachial index(ABI) and hemorheology changes before and after the use of ginkgo-damole combined with prostaglandin E1 in diabetic patients with PAD. Result The total effective rate was 91.2% in therapeutic group, and the significant efficiency in therapeutic group was higher than that in control group ( 67.6% vs 36.7% ) ( P ＜ 0. 05 ). Compared with before the treatment , ABI increased significantly and hemorheological parameters improved significantly in two groups after the treatment( P ＜ 0. 05 or P ＜ 0. 01 ), and the difference were more significant in therapeutic group than in control group( P ＜ 0. 05 or P ＜ 0. 01 ). Conclusion Ginkgo-damole combined with prostaglandin E1 was effective and safe in treatment of diabetic patients with PAD.