Placental apoptosis in preeclampsia / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 787-792, 2001.
Article
Dans Coréen
| WPRIM
| ID: wpr-41532
ABSTRACT
OBJECTIVE:
Our purpose was to investigate the incidence of placental apoptosis in pregnancies complicated by preeclampsia.METHODS:
Placental samples were obtained from 15 uncomplicated third-trimester pregnancies and from 17 pregnancies complicated by preeclampsia. TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling) staining and electron microscopy were performed on all placental samples and identified apoptosis within the cells of the placenta. TUNEL positive stained cells were counted at each photograph(five sections were photoragphed at 1,500 magnifications for each sample). We focused on only the syncytiotrophoblast nuclei of the placenta. The number of apoptotic syncytiotrophoblast nuclei identified was expressed as a percentage of total number of syncytiotrophoblast nuclei counted.RESULTS:
Quantification of apoptosis (mean+/-SD) was as follows normal third trimester (n=15) 0.57+/- 0.47% of cells and preeclampsia third trimester (n=17) 1.41+/-0.67% of cells. The incidence of apoptosis was significantly increased in placentas from pregnancies with preeclampsia compared with normal placentas (p< 0.01).CONCLUSION:
These results suggest that placental apoptosis may play a role in the pathophysiologic mechanisms of preeclampsia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Placenta
/
Pré-éclampsie
/
Troisième trimestre de grossesse
/
Trophoblastes
/
Microscopie électronique
/
Incidence
/
Apoptose
/
Méthode TUNEL
/
Désoxyuridine
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Grossesse
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2001
Type:
Article
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