Electrophysiological study on the modulation of uterine mechanoreceptor by substance P / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 740-747, 2001.
Article
Dans Coréen
| WPRIM
| ID: wpr-41538
ABSTRACT
OBJECTIVE:
In inflammation, hyperalgesia is a common phenomenon but its mechanism has not been clarified. Recently some reports suggested substance P might be important factors for inflammatory hyperalgesia in somatic tissue. This study was performed to see whether substance P modulate the activities of uterine afferent fibers in the hypogastric nerve of the cat.METHODS:
While recording the electrical activities of nerve fibers, mechanical stimuli were applied as balloon distention using balloon inserted into uterine lumen before and during substance P infusion through uterine artery.RESULTS:
Substance P increased the responses to balloon distension of uterus in 14 uterine mechanoreceptive afferent fibers of 24 over 10% compared to before substance P infusion, and decreased the responses of 3. And L-703,606, the neurokinin 1 receptor antagonist failed the modulation of mechano sensitive response by substance P and reduced the spontaneous activities.CONCLUSIONS:
These results suggest that substance P modulated the activities of uterine nerve fibers and their responses to mechanical stimulus. It is hypothesized that this kind of modulation of afferent nerve fibers by substance P may be important for the development of inflammatory hyperalgesia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Utérus
/
Substance P
/
Récepteur de la neurokinine 1
/
Artère utérine
/
Hyperalgésie
/
Inflammation
/
Mécanorécepteurs
/
Neurofibres
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2001
Type:
Article
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