Anterior pituitary hypofunction: a clinical analysis of 117 cases / 中华内分泌代谢杂志

ABSTRACT

Objective To investigate the clinical features of anterior pituitary hypofunction.Methods A retrospective analysis was carried out on the data of 117 patients with anterior pituitary hypofunction during 1994-2010.Results There were 60.68％ male and 39.32％ female patients respectively.The onset age was from 13 to 79 years,with 79.12％ of the patients more than 40 years old.There were 57 cases with sellar tumors ( 40.17％ ),in which 55 cases( 96.49％ )were operated and (or) treated with radiotherapy.35 cases were operated via the frontal approaches( 66.04％ ) and 18 cases underwent transsphenoidal surgery ( 33.96％ ).There were 108 cases with hyponatremia with the first symptoms of weakness,anorexia,nausea,and vomiting induced by ACTH deficiency (92.31％ ).There were 23 cases accompanied with central diabetes insipidus( 19.66％ )and 82 cases with coronary heart disease( 70.09％ ).Conclusion Owing to the difference in etiological factors,the incidence,early symptoms,and the hormones involved are greatly different.The main cause is pituitary tumor,which occured more in aged person,more in males than females.