The detection and significance of hyper sensitivity C-reactive protein, iipoprotein (a) and total cholesterol/high density lipoprotein cholesterol in coronary heart disease / 中国医师进修杂志

ABSTRACT

ObjectiveTo analyze the significance of serum hyper sensitivity C-reactive protein (hs-CRP),lipoprotein (a) [ Lp(a) ] and total cholesterol (TC)/high density lipoprotein cholesterol ( HDL-C )in coronary heart disease.Methods From September 2010 to September 2011,the levels of serum hs-CRP,Lp (a) and TC/HDL-C were detected in 176 patients of coronary heart disease (coronary heart disease group ) and 60 healthy controls (control group).Coronary heart disease group included acute myocardial infarction with 56 cases,stable angina with 58 cases and unstable angina with 62 cases.ResultsThe levels of serum hs-C RP,Lp ( a ) and TC/HDL-C in coronary h cart disease group were (34.51 ± 9.65 ) mg/L,(295.16 ±104.57) mg/L and 4.23 ±0.91,while those in control group were (1.26 ±0.69) mg/L,(145.26 ±42.19)mg/L and 2.54 ± 0.57.There were significant differences between two groups (P ＜ 0.05 ).The levels of serum hs-CRP,Lp(a) and TC/HDL-C in acute myocardial infarction patients were significantly higher than those in unstable angina patients and stable angina patients (P ＜ 0.05).The levels of serum hs-CRP,Lp (a) and TC/HDL-C in unstable angina patients were significantly higher than those in stable angina patients(P ＜ 0.05).Conclusions Serum hs-CRP,Lp (a) and TC/HDL-C are significantly increased in coronary heart disease,and can reflex the severity of coronary heart disease.