Infection schedule and pathogens characteristics after liver transplantation / 中华肝胆外科杂志

ABSTRACT

With the development of immunosuppressant and surgical technique,both the survival rate of liver transplant patients and grafts improve significantly. Meanwhile,infection has become one of the most common complication and main reason of death.The knowledge of the characteristics of infection after liver transplantation is helpful for early diagnosis and treatment,which may decrease the mortality.As the clinical manifestation becomes atypical for the usage of immunosuppressant, it's reasonable to combine some specific biomarkers for early diagnosis.Pathogen varies according to the time post transplant,and it can be divided into three stages.Low immune status and the application of broad-spectrum antibiotic are the reason of opportunistic infection and super infection. Epidemiological survey found that new type of fungus and multi-drug resistance bacterium increase.It's important to pay attention to the management and standardized usage of antibiotic,as well as to establish relative guideline,which may decrease the drug resistance and improve outcome.