Profiling of human herpesvirus-8 (HHV-8) K15 allelotypes in squamous cell carcinoma tissue / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12): 636-638, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-421641
ABSTRACT
Objective To study the relationship of HHV-8 K15 allelotypes in cutaneous and esophageal squamous cell carcinoma(SCC) tissue with tumorigenesis. MethodsSequence specific primernested PCR was performed to detect HHV-8 K15 gene and to determine its allelotype in paraffin-embedded tissue specimens from 40 patients with cutaneous SCC and 40 patients with esophageal SCC. Chi-square test was used for statistical analysis. ResultsHHV-8 K15 P allele was detected in 9(22.5%) of the cutaneous SCC specimens and 8(20%) of the esophageal SCC specimens. There was no significant difference in the detection rate of HHV-8 between cutaneous SCC and esophageal SCC specimens (P > 0.05). HHV-8 K15 M allele was undetected in this study. ConclusionsSCC tissues appear to harbor only HHV-8 K15 P allele, and HHV-8 may play a part in the initiation and progression of SCC.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Dermatology
Année:
2011
Type:
Article
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