Clinical observation on rabeprazole combined with mosapride in treatment of reflux esophagitis / 中国基层医药

ABSTRACT

ObjectiveTo study the the efficacy and safety of joint rabeprazole mosapride treatment of reflux esophagitis(RE). Methods110 patients Confirmed by endoscopy reflux esophagitis were randomly divided into treatment group and control group 55 cases. Treatment grouporal rabeprazole 10mg, sooner or later, a second fasting taking each mosapride 5mg,3 times/day, fasting and a half hours to take; control group omeprazole 20mg/day, taken before meals ,mosapride taking followed. 2 groups of patients were completed 6 weeks of treatment ,the clinical efficacy and safety were observed. ResultsThe clinical total effective rate of symptom relief( symptom improvement and endoscopic remission and mucosal lesions ) were 94.5％ for the treatment group ( 52/55 ), control group 76.4％ ( 42/55), the efficiency of the treatment group was superior in the control group ( P ＜ 0.05 ). ConclusionRabeprazole joint mosapride treatment of reflux esophagitis could improve symptoms rapidly,and clinical efficacy was superior to omeprazole mosapride treatment of reflux esophagitis, and was safe and reliable.