Expression significance of Cyclin E in gastric cancer and lymphonode metastatic cancer / 中国医师杂志
Journal of Chinese Physician
; (12): 1320-1322, 2011.
Article
de Zh
| WPRIM
| ID: wpr-422733
Bibliothèque responsable:
WPRO
ABSTRACT
Objective This study aimed to investigate the expression of Cyclin E protein in the progress of occurrence and development of gastric cancer and lymphonode metastatic cancer.Methods The expression of Cyclin E protein analyzed by immunohistochemistry in gastric tissue array included of normal gastric mucosa,cancer side tissues,atypical hyperplasia tissues,primary cancer tissues and lymphonode metastatic cancer tissues.Results The positive expression rate of Cyclin E protein was 14.3%,20.0%,34.7%,85.1% and 82.9% in normal gastric mucosa,atypical hyperplasia tissue,carcinoma side tissue,primary cancer and lymphonode metastatic cancer,respectively.Compared with normal gastric mucosa and carcinoma side tissues and atypical hyperplasia tissues,the Cyclin E protein in primary cancer and lymphonode metastatic carcinoma tissues was over-expression ( P < 0.01 ).Conclusions The Cyclin E protein was a possible molecular marker that can be used to diagnosis gastric cancer and lymphaden metastasis cancer.
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WPRIM
langue:
Zh
Texte intégral:
Journal of Chinese Physician
Année:
2011
Type:
Article