Effect of Baweichenxiang powder on acute hypoxic cerebral ischemia-reperfusion injury in rats / 国际中医中药杂志

ABSTRACT

ObjectiveTo observe the protection of Baweichenxiang powder on cerebral ischemia-reperfusion injury in rats.MethodsSD rats were randomly divided into six groups,namely,sham operation group,model group,nimodipine group,Baweichenxiang powder high,medium and low-dose group.Cerebral ischemia-reperfusion rat model was established by gavage.Observe the effects of different doses of Baweichenxiang powder on behavior in rats,brain water content,infarct size,SOD,MDA and morphological changes.ResultsCompared with the control group,Baweichenxiang powder significantly reduced behavioral score (P＜0.05),reduced brain edema,decreased infarct size,improved brainmorphological changes,increased SOD activity(P＜0.05,P＜0.01)and reduced the MDA content(P＜0.05).ConclusionBaweichenxiang powder of high dose and middle dose have significant protective effect for cerebral ischemia,the mechanism may be related to its improving levels of free radicals and lipid peroxidation.