No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
Psychiatry Investigation
;
: 180-189, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-42589
ABSTRACT
OBJECTIVE:
Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated.METHODS:
One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417).RESULTS:
IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome.CONCLUSION:
Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Psychothérapie
/
Sérotonine
/
Assistance
/
Récepteur de la sérotonine de type 5-HT1A
/
Récepteur de la sérotonine de type 5-HT2A
/
Dépression
/
Trouble dépressif majeur
/
Transporteurs de la sérotonine
/
Génotype
/
Antidépresseurs
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Psychiatry Investigation
Année:
2013
Type:
Article
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