Negative regulation of transforming growth factor-β superfamily co-receptor Ⅲ in tumorigenesis / 国际肿瘤学杂志
Journal of International Oncology
; (12): 411-414, 2012.
Article
Dans Zh
| WPRIM
| ID: wpr-426121
Responsable en Bibliothèque :
WPRO
ABSTRACT
The expression of transforming growth factor(TGF)-β supeffamily co-receptor (Tβ3R) Ⅲ is often lost in many kinds of cancers.Tβ3RⅢ plays a role of negative regulation in tumorigenesis.T3RⅢ could regulate the cellular invasion,migration,proliferation and apoptosis by multiple mechanisms,such as mediating the TGF-β signaling pathway,impacting the mitogen-activated protein kinase(MAPK),nuclear factor-kappa B (NF-κB) and Cdc42 and producing soluble TβR(sTβR) Ⅲ.Defining the mechanisms of absence and physiological functions of TβR Ⅲ in cancers has great significant for the diagnosis,treatment and prognosis of cancer.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
Journal of International Oncology
Année:
2012
Type:
Article