Clinical significance of lndoleamine 2,3-dioxygenase (IDO) and B7-H1 expressions in pancreatic carcinoma patients undergone pancreatoduodenectomy / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 503-507, 2012.
Article
de Zh
| WPRIM
| ID: wpr-426760
Bibliothèque responsable:
WPRO
ABSTRACT
ObjectiveTo analyze the relationship between expressions of Indoleamine 2,3-dioxygenase (IDO) and B7-H1 with clinico-pathological features and their prognostic significance in pancreatic cancer (PC).Method95 patients who underwent radical pancreaticoduodenectomy for PC were studied.The IDO and B7-H1 expressions in tissue specimens were determined by immunohistochemistry.ResultsIDO and B7-H1 expressions were higher in pancreatic carcinoma tissues than in normal pancreatic tissues (P<0.05).IDO and B7-H1 expressions positively and significantly correlated with pathological grades and tumour-node-metastasis (TNM) stages (P<0.05).They were prognostic of poor cancer-specific survival.After adjusting by the Cox proportional hazards regression models (P<0.05),only a combined IDO/B7-H1 expression served as an independent prognostic marker.ConclusionsIDO and B7-H1 were expressed in PC,and they were important markers for malignant progression of PC.A combined IDO/B7-H1 expression served as an independent prognostic marker for PC.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
Chinese Journal of Hepatobiliary Surgery
Année:
2012
Type:
Article