Association of single nucleotide polymorphism of interleukin 6 receptor gene and metabolic syndrome / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 572-574, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-427221
ABSTRACT
The association of interleukin 6 receptor ( IL-6R ) gene - 183 A/G ( rs4845617 ) and Asp358 Ala (rs8192284 A/C) polymorphisms with metabolic syndrome was investigated in Chinese Han population.The result showed that the frequencies of AA genotype and A allele were higher in patients with metabolic syndrome ( MS ) than those in healthy subjects ( P<0.05 or P<0.01 ).The risk of MS in patients with A allele was 1.643 folds of that with allele C(95% CI 1.163-2.320,P<0.01 ).No differences were found in the genotype and allele frequencies of -183A/G between two groups ( P>0.05 ).The Asp358Ala polymorphism of IL-6R was significantly associated with MS in Chinese Han population.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Endocrinology and Metabolism
Année:
2012
Type:
Article
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