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Comparative study on the clinical outcome following different doses of amphotericin B liposome in the treatment of patients with invasive pulmonary fungal infections after renal transplantation / 中华器官移植杂志
Article de Zh | WPRIM | ID: wpr-427468
Bibliothèque responsable: WPRO
ABSTRACT
ObjectiveTo compare the clinical effectiveness and adverse effects following low doses versus traditional doses of amphotericin B liposome (L-AmB) in the treatment of patients with invasive pulmonary fungal infections (IPFI) after renal transplantation.MethodsA total of 26 postrenal transplantation patients with IPFI between Jan. 2005 and Mar. 2011in Zhujiang hospital received L-AmB treatment identified low doses group (0.2-0.5 mg·kg-1·d-1,n =19) or traditional doses group (1-5 mg· kg-1,d-1,n =7) were reviewed.ResultsThe treatment duration in low doses group and traditional doses group was 20.3 +12.7 and19.3 ±13.2 days respectively (P>0.05).The effective rate in low doses group and traditional doses group was 84.2% and 57.1% respectively (P>0.05).The overall dosage was significantly less in the low doses group (414.7 ± 241.7 mg) than in the traditional doses group (1158.8 ± 928.0 mg) (P<0.05).The incidence of adverse effect was significantly lower in the low doses group than in the traditional doses group (21.1% vs.85.7%,P<0.05).ConclusionThe effectiveness of low doses of L-AmB protocol in the treatment of IPFI postrenal transplantation patients was similar to that of traditional doses of L-AmB protocol,but the incidence of adverse effects in low doses of L-AmB protocol was significantly lower.
Mots clés
Texte intégral: 1 Indice: WPRIM Type d'étude: Guideline langue: Zh Texte intégral: Chinese Journal of Organ Transplantation Année: 2012 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Guideline langue: Zh Texte intégral: Chinese Journal of Organ Transplantation Année: 2012 Type: Article