The expression and clinical significance of VEGF-C and CD24 in lung cancer / 中华胸心血管外科杂志

ABSTRACT

Objective To study the expressions of VEGF-C and CD24 in lung cancer and their clinical significance,and to discuss the relationship between their expressions as well.Methods The methods of RT-PCR and immunohistochemical staining are adopted.The expression levels of VEGF-C,CD24 mRNAs and proteins in 138 primary lung cancer patients'cancer tissues and paracancerous tissues are detected.Results (1) The expression levels of VEGF-C,CD24 mRNA and proteins in lung cancer tissues are all higher than those in paracancerous tissues (P ＜ 0.05).There is evident positive correlativity between the expressions of VEGF-C and CD24 in lung cancer(P ＜ 0.05) (2) The expression levels of VEGF-C,CD24 mRNA and proteins in the metastasis group are all higher than those in the non-metastasis group (P ＜ 0.05).(3) There is evident correlativity between the expression of VEGF-C,CD24 and lymph node metastasis,TNM staging(P ＜ 0.05).(4) The expressions of VEGF-C,CD24 mRNA and proteins are both related to the short-term prognosis of the Stage ⅢA patients.Conclusion VEGF-C and CD24 are both abnormally expressed in lung cancer tissues,which can be used as a marker of lung cancer diagnosis.