Update on the pathogenesis of hyper IgM syndrome / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 10-13, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-430185
ABSTRACT
The hyper immunoglobulin M syndromes(HIGM) are a heterogeneous group of genetic disorders resulting in defects of immunoglobulin class switch recombination,with or without defects of somatic hypermutation.They can be classified as defects of signalling through CD40 causing combined immunodeficiency,or intrinsic defects in B cells of the mechanism of class switch recombination resulting in a pure humoral immunodeficiency.This review summarizes the molecular pathogenesis of HIGM.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude d'étiologie
langue:
Chinois
Texte intégral:
International Journal of Pediatrics
Année:
2013
Type:
Article
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