Progress on the molecular mechanisms of neuroglobin improving neonatal hypoxia-isehemia brain injury / 国际儿科学杂志

ABSTRACT

Neuroglobin is involved in neuroprotection from damage due to hypoxia or ischemia in vitro and in vivo.Overexpression of neuroglobin ameliorates the recovery from hypoxia-ischemia brain injury in experimental animals.The mechanism is still unknown.Studies have revealed that neuroglobin has a typical globin fold,and despite being hexacoordinated,which binds reversibly O2,CO2,and NO.This article reviews the possible mechanisms involved in neuroprotection of neuroglobin and provide a clue in treatment of hypoxia-ischemia brain injury.