Clock genes' regulatory influence to saccharometabolism / 国际儿科学杂志

ABSTRACT

Circadian rhythm,as the most common biological rhythm of the biosphere,exists in almost all organisms.The circadian rhythm center of mammals and humans is in the suprachiasmatic nucleus of the hypothalamus and circadian oscillation is also found in peripheral organ.By the united integration of neurohumor and external synchronous,these two regulate various physiological activities and behavior processes of organisms.The disturbance of circadian clock causes impaired glucose tolerance and insulin secretory abnormalities,which further results in abnormal glucose metabolism.Another reason for impaired glucose metabolism is the movement of circadian clock phases caused by glucose,illumination,shift and diet.The review summarizes the clock genes'regulatory influence on saccharometabolism.