Relationship between the expression of SOCS-1/3 in the peripheral blood mononuclear cells and interferon therapeutic response in patients with chronic hepatitis B / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 1921-1923, 2013.
Article
de Zh
| WPRIM
| ID: wpr-434573
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WPRO
ABSTRACT
Objective To investigate the relationship between the the expression of SOCS-1/3 in the peripheral blood mononuclear cells (PBMCs) and interferon therapeutic response in patients with chronic hepatitis B.Methods 50 patients with chronic hepatitis B were given interferon therapy.After 24 weeks treatment,according to biochemical and virologic response,they were divided into two groups:response and non response group.HBV-DNA was detected by PCR.The SOCS-1/3 mRNA levels were measured by RT-PCR.Results The expression of SOCS-1 in the PBMCs of response group after 24 weeks treatment was significantly higher than that before interferon therapy (P < 0.05).The expression of SOCS-3 in the PBMCs of response group after 24 weeks trentment was significantly lower than that before interferon therapy (P < 0.05).In non response group,there were no significant differences in the expression of SOCS-1/3 (P > 0.05).Conclusion The increase expression of SOCS-1 mRNA and the decrease of SOCS-3 mRNA in the PBMCs in chronic hepatitis B patients received 24 weeks interferon-therapy probably is relevant to the IFN-α antiviral effect.
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WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Primary Medicine and Pharmacy
Année:
2013
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Article