Expression and significance of BCAR1 in endometrial carcinomas / 中国综合临床
Clinical Medicine of China
; (12): 561-564, 2013.
Article
de Zh
| WPRIM
| ID: wpr-434737
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To investigate the expression and significance of BCAR1 protein in endometrial carcinoma.Methods The level of BCAR1 was measured by immunohistochemistry in 50 endometrial carcinoma samples and 30 normal proliferative endometrium samples.Estrogen receptor (ER) and progesterone receptor (PR) expression was investigated in endometrial carcinoma samples.Results The level of BCAR1 was higher in endometrial carcinoma than that in normal proliferative endometrium (64.0% (32/50) vs.40.0% (12/30) ;x2 =4.364,P =0.037).In endometrial cancer,increased BCAR1 expression was significantly correlated with relatively higher age,poor differentiation,positive expression of ER (x2 =6.272,r =0.354 ; x2 =5.640,r =0.366 and x2 =4.217,r =0.290 ; P < 0.05).Conclusion BCAR1 promote carcinogenesis and positively correlate with poor differentiation and ER status in endometrial carcinoma.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Clinical Medicine of China
Année:
2013
Type:
Article