Cancer Treatment near the End-of-Life Becomes More Aggressive: Changes in Trend during 10 Years at a Single Institute / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 555-563, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-43517
ABSTRACT
PURPOSE:
The purpose of this study was to investigate and compare cancer treatment near the end-of-life (EOL) over a 10-year period. MATERIALS ANDMETHODS:
Patients with advanced solid cancer at Seoul National University Hospital who received palliative chemotherapy and had died were enrolled. We categorized the consecutive patients according to two time periods 2002 (n=57) and 2012 (n=206). Aggressiveness of cancer treatment near the EOL was evaluated.RESULTS:
The median patient age was 62, and 65.4% of patients (n=172) were male. Time from the last chemotherapy to death (TCD) was found to have been significantly shortened, from 66.0 days to 34.0 days during 10 years (p < 0.001); 17% of patients received molecular targeted agents as the last chemotherapy regimen in 2012. The proportion of patients who received intensive care unit care within the last month increased from 1.8% in 2002 to 19.9% in 2012 (p < 0.001), and emergency room visits within the last month also increased from 22.8% to 74.8% (p < 0.001). Although hospice referral increased from 9.1% to 37.4% (p < 0.001), timing of referral was delayed from median 53 days to 8 days before death (p=0.004). Use of targeted agents as the last chemotherapy for over-two-regimen users was associated with shortened TCD (hazard ratio, 2.564; p=0.002).CONCLUSION:
Cancer treatment near the EOL became more aggressive over 10 years.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Orientation vers un spécialiste
/
Soins terminaux
/
Traitement médicamenteux
/
Service hospitalier d'urgences
/
Thérapie moléculaire ciblée
/
Séoul
/
Établissements de soins palliatifs
/
Unités de soins intensifs
Limites du sujet:
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Cancer Research and Treatment
Année:
2015
Type:
Article
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