Curative effect of drugs on primary sclerosing cholangitis / 中国基层医药

ABSTRACT

Objective To investigate the clinical effect of internal medicine medical treatment on primary sclerosing cholangitis disease.Methods Patients with primary sclerosing cholangitis in the study group were given ursodeoxycholic acid and glucocorticoid combined with the comprehensive drug treatment on the basis of conventional therapeutic measures.Patients with primary sclerosing cholangitis in the control group were simply given corticosteroid drugs prednisone therapy,The clinical symptoms,results of clinical medical imaging examination,laboratory examination indexes and liver histological recovery were recorded and analyzed in two groups before and after treatment.Results The total effective rate of the study group was 86.96％,which was significantly higher than that of the control group 65.22％ (P ＜ 0.05).The curative effect between the two groups had statistically significant difference.Conclusion Ursodeoxycholic acid and lucocorticoid combined with drug treatment can improve the clinical symptoms and physical indexes in treatment of patients with primary sclerosing cholangitis,which is worthy of clinical application,but still need to give liver transplant operation.