Influence of Yigu oral Liquid on Inhibiting Pain in Ovariectomized Rats / 浙江中医药大学学报

ABSTRACT

[Objective]To observe the influence of Yigu oral liquid on inhibiting the pain in ovariectomized rats by detecing the pain threshold, bone densi-ty, serum inflammatory factor, vascular endothelial function(ET) and platelet activating capacity(CD62p and CD63).[Method]80 SD rats were randomly di-vided into four groups of sham group, Yigu oral liquid group, Miacalcic group,control group. There were 20 in each group.Yigu oral liquid group,Mia-calcic group,control group were ovariectomized,sham group underwent sham operation. After confirming the successful model of osteoporosis, sham group was administrated with saline, Miacalcic saline group was administrated with Miacalcic by intramuscular injection ,Yigu oral liquid group was administrated with Yigu oral liquid ,saline and control group was administrated with saline.The indicators of pain threshold,bone density,vascular endothelial function (ET) and platelet activating capacity(CD62p and CD63), serum inflammatory factors as COX-2, PGE2, cAMP were respectively detected. [Results] The levels of peripheral inflammatory factors as COX-2, PGE2, cAMP , vascular endothelial function(ET) and platelet activating capacity(CD62p and CD63)of Yigu oral liquid group decreased significantly compared with the control group( P<0.05). The level of pain threshold and bone density of Yigu oral liquid group improved significantly compared with the control group(P<0.05).[Conclusion]Yigu oral liquid can inhibit osteoporosis pain by improving the level of pain threshold ,bone density,and decreasing the levels of COX-2, PGE2, cAMP, vascular endothelial function(ET) and platelet activating capacity (CD62p and CD63).