Related molecules for regulating autophagy of tumor cells / 国际肿瘤学杂志

ABSTRACT

Autophagy is an important physiological process in eukaryotic cells and is contributive to normal update of cellular components.When the body is in hunger state,autophagy can not only produce amino acid and ATP through degrading proteins to provide conditions for cell survival,but also remove the damaged organelles to maintain the normal functions of cells.The abnormal functions of autophagy are closely related to the formation and development of tumors,and the degree which is too high or too low both can inhibit tumors.It has been found that autophagy is regulated by many kinds of molecules,and the results are different.So in-depth studies on the mechanisms of these autophagy-related molecules will become a starting point for further understanding the autophagy and a sally port for treating tumors.