CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
Annals of Laboratory Medicine
;
: 95-98, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-43978
ABSTRACT
The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Translocation génétique
/
Moelle osseuse
/
Chromosomes humains de la paire 3
/
Chromosomes humains de la paire 11
/
Chromosomes humains de la paire 14
/
Réarrangement des gènes
/
Protéines de fusion oncogènes
/
Immunophénotypage
/
Protéines proto-oncogènes c-myc
/
Hybridation fluorescente in situ
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Aged80
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Annals of Laboratory Medicine
Année:
2012
Type:
Article
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