A Comparison of The Induction Characteristics of Propofol and Thiopental on The Hypertensive Patients / 대한마취과학회지

ABSTRACT

We have compared the cardiovascular effects during intravenous induction and endotracheal intubation with propofol or thiopental sodium on the forty hypertensive patients. Propofol was given 2 mg/kg or thiopental sodium was given 5 mg/kg intravenously for induction of general anesthesia, and endotracheal intubation. The patients were allocated in two groups according to the intravenous anesthetic sgents that were administered (Group I; 20 patients Propofol group and Group II; 20 patients Thiopental group), Arterial blood pressure and heart rate was recorded by automatic noninvasive blood pressure cuff (ESCORT 100/200 Medical Data Electronics. Arleta Ca. U.S.A.). Systolic, diastolic arterial blood pressure, and heart rates were recorded 1 minute before administration of intravenous anesthetic agents, 1 minute and 5 minutes after endotracheal intubation. Reduction of systolic and diastolic arterial blood pressure were significantly greater after propofol(30%) than thiopental sodium administration and intubation. The change of the heart rate after propofol induction and intubation was not significant. However, the heart rate was increased about 23% after thiopental sodium induction and intubation. The results of this study indicate that propofol 2 mg/kg intravenous induction and intubation for hypertensive surgical patient should be contribute to patients prognosis.