Sodium deoxyribonucleotide intervention in wound healing / 中国医师杂志

ABSTRACT

Objective To evaluate the efficacy and safety of deoxyribonucleotide in intervention with wound healing.Methods A total of 144 patients above Type Ⅱ incision was included.All patients were received conventional therapy.And 72 cases in positive group were given thymopentin 1mg/d for 7 ～14 days,72 patients in treatment group were given deoxyribonucleotide 200mg/d for 7 ～ 14 days.Wounds were observed at 7,14,30 days,respectively.Results Postoperative infection rate(12.1％ vs 16.6％ vs 40％,P ＜ 0.05),pathogenic bacteria detection were decreased by both treatment and control groups.The 14 d complete healing rate (80％ vs 48.3 ％,P ＜ 0.05),weight gain [(2.1 ± 0.7) kg vs (0.6 ± 0.3) kg,P=0.016],clinical effect (89.3％ vs 61.3％,P =0.0018) of treatment group were higher than the control group.The 7 d wound area and complete healing time of treatment group were lower than the control group [(12.6 ±6.8)cm2 vs (18.7 ±7.1)cm2,P =0.018; (18.8 ± 11.2)d vs (21.4 ± 12.6)d,P =0.023].Deoxyribonucleotide can promote fibroblast proliferation and collagen production [(35.4 ± 7.6)ng/L vs (24.4 ± 6.9) ng/L,P =0.006].Conclusions Short-term application of deoxyribonucleotide and thymopentin can decrease postoperative infection through activating immune function.However,wound healing had no relationship with activating immune function seemly.Deoxyribonucleotide promotes wound healing through promoting fibroblast proliferation.