Advances in oncolytic adenovirus-loaded mesenchymal stem cells for treating tumors / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 266-268, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-443791
ABSTRACT
Oncolytic adenoviruses have been used in cancer gene therapy because of their ability to selectively transfect and repli-cate in tumor cells. However, systemically administering oncolytic adenoviruses is often inefficient because the host's immunity also at-tacks the viruses. Delivering oncolytic adenoviruses by loading them into mesenchymal stem cells effectively solves this problem. Mes-enchymal stem cells have been described to possess a tumor-homing ability, as well as the capacity to deliver oncolytic adenoviruses. This review discusses the current challenges faced by oncolytic adenovirus delivery via mesenchymal stem cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Clinical Oncology
Année:
2014
Type:
Article
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