Moderate hypofractionated image-guided thoracic radiotherapy for locally advanced node-positive non-small cell lung cancer patients with very limited lung function: a case report
Radiation Oncology Journal
; : 180-184, 2017.
Article
de En
| WPRIM
| ID: wpr-44434
Bibliothèque responsable:
WPRO
ABSTRACT
Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second [FEV1] ≤ 1 L) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes. Planning was based on positron emission tomography-computed tomography (PET/ CT) and four-dimensional computed tomography (4D-CT). Internal target volume (ITV) was defined as the overlap of gross tumor volume delineated on 10 phases of 4D-CT. ITV to planning target volume margin was 5 mm in all directions. Both patients showed good clinical and radiological response. No relevant toxicity was documented. Hypo-IGRT is feasible treatment option in locally advanced node-positive NSCLC patients with very limited lung function (FEV1 ≤ 1 L).
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Soins palliatifs
/
Pronostic
/
Radiothérapie
/
Carcinome pulmonaire non à petites cellules
/
Charge tumorale
/
Électrons
/
Tomodensitométrie 4D
/
Chimiothérapie d'induction
/
Radiothérapie guidée par l'image
/
Poumon
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Radiation Oncology Journal
Année:
2017
Type:
Article