Evaluation of adjuvant effects of fucoidan for improving vaccine efficacy
Journal of Veterinary Science
; : 145-150, 2015.
Article
de En
| WPRIM
| ID: wpr-44468
Bibliothèque responsable:
WPRO
ABSTRACT
Fucoidan is a sulfated polysaccharide derived from brown seaweed, including Fucus vesiculosus. This compound is known to have immunostimulatory effects on various types of immune cells including macrophages and dendritic cells. A recent study described the application of fucoidan as a vaccine adjuvant. Vaccination is regarded as the most efficient prophylactic method for preventing harmful or epidemic diseases. To increase vaccine efficacy, effective adjuvants are needed. In the present study, we determined whether fucoidan can function as an adjuvant using vaccine antigens. Flow cytometric analysis revealed that fucoidan increases the expression of the activation markers major histocompatibility complex class II, cluster of differentiation (CD)25, and CD69 in spleen cells. In combination with Bordetella bronchiseptica antigen, fucoidan increased the viability and tumor necrosis factor-alpha production of spleen cells. Furthermore, fucoidan increased the in vivo production of antigen-specific antibodies in mice inoculated with Mycoplasma hyopneumoniae antigen. Overall, this study has provided valuable information about the use of fucoidan as a vaccine adjuvant.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polyosides
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Rate
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Vaccins antibactériens
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Marqueurs biologiques
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Cellules cultivées
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Adjuvants immunologiques
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Régulation de l'expression des gènes
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Cytokines
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Bordetella bronchiseptica
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Fucus
Limites du sujet:
Animals
langue:
En
Texte intégral:
Journal of Veterinary Science
Année:
2015
Type:
Article