Efficacy of Domperidone Combined with Pantoprazole and Hydrotalcite Tablets in the Treatment of Bile Reflux Gastritis / 中国药师
China Pharmacist
;
(12): 842-844, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-445963
ABSTRACT
Objective:
To observe the curative effects of the combined application of domperidone, pantoprazole and hydrotalcite tablets in the treatment of bile reflux gastritis ( BRG) and explore the underlying mechanism.Methods:
Totally 80 patients with BRG were randomly divided into the treatment group and the control group with 40 cases in each. The treatment group was received panto-prazole, hydrotalcite tablets and domperidone, and the control group was treated by hydrotalcite tablets and domperidone. The efficacy was observed in both groups after 4 weeks.Results:
The effective rate of symptom relief in the treatment group and the control group was respectively 92. 5% and 62. 5% (P<0. 05). After the 4 week treatment, the gastritis healing rate in the treatment group was higher than that in the control group (P<0. 05). The improvement of gastric mucosal hyperemia, edema and erosion in the treatment group was better than that in the control group with significant difference (P<0. 05). Cholic acid in gastric juice and gastric acid se-cretion were significantly reduced in both groups after the treatment, while the reduction of gastric acid secretion in the treatment group was more notable than that in the control (P<0. 05).Conclusion:
Pantoprazole can be used to control BRG, and the combination of the three drugs shows better efficacy in the treatment of BRG.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacist
Année:
2014
Type:
Article
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