A study on characteristics of rifampin-and isoniazid-resistance genes of Mycobacterium tuberculosis in Ganzhou region / 国际检验医学杂志
International Journal of Laboratory Medicine
; (12): 1136-1137, 2014.
Article
Dans Zh
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| ID: wpr-446199
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To investigate the characteristics of rifampin(RFP) and isoniazid(INH) resistance genes of Mycobacteri-um tuberculosis in Ganzhou region .Methods Gene chip technology was employed to detect common resistance genes in 130 sputum samples with smear positive acid-fast staining and Ct values less than 30 .Results Among 130 samples ,34 samples(26 .2% ) were found resistance ,including 30 samples(23 .1% ) resistant to RFP ,26 samples(20 .0% ) resistant to INH ,and 21 samples(16 .2% ) resistant to both .The mainly mutation of RFP resistant gene was rpoB gene 531(C→ T ) ,accounting for 42 .4% ,while the mainly mutation of INH resistant gene was katG gene 315(AGC→ACC) ,accounting for 65 .4% .Conclusion The mutation charateristics of RFP and INH resistance-associated genes of Mycobacterium tuberculosis in Ganzhou region is consistent with domestic and foreign research .
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International Journal of Laboratory Medicine
Année:
2014
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Article