Correlation of Pre-treatment FDG Uptake to Therapeutic Response and Relapse in Patients with Small Cell Lung Cancer / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
;
: 538-545, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-44658
ABSTRACT
PURPOSE:
We evaluated correlation of 18F-FDG uptakes, therapeutic response and relapse in pre-treatment 18F-FDG PET/CT in patients with SCLC. MATERIALS ANDMETHODS:
We included 26 patients with pathologically proven small cell lung cancer. Total 102 lesions (26 lungs, 69 lymph nodes and 8 metastatic lesions) were evaluated. All patients underwent 18F-FDG PET/CT for staging. The maxSUV was used as a parameter of 18F-FDG uptake. The patients were divided into responders and non-responders according to response criteria on chest CT scan after 3 cycles of chemotherapy. We compared maxSUV between two groups by using independent t-test. To access correlation with 18F-FDG uptake and relapse, maxSUV and interval time to relapse was analyzed by correlation analysis. The cutoff value of maxSUV was evaluated by ROC curve.RESULTS:
Twelve-one patients (81%) were responders and five patients were non-responders on follow-up chest CT scan. The mean maxSUV of main lung lesions in responders and non-responders were 14.15+/-3.72 and 9.17+/-2.15, respectively. The maxSUV in the responders was significantly lower than that in non-responders (p<0.05). According to ROC curve, point of cut that predicts therapeutic response was 8.98 with 100% sensitivity and 57% specificity. The correlation analysis between 18F-FDG uptakes and interval time to relapse showed a significant negative correlation (p<0.05, r=-0.757).CONCLUSION:
The pre-treatment 18F-FDG uptake of responders was significantly lower than that of non-responders. Patients with high 18F-FDG uptake in pre-treatment 18F-FDG PET/CT relapse earlier.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récidive
/
Tomodensitométrie
/
Courbe ROC
/
Études de suivi
/
Sensibilité et spécificité
/
Fluorodésoxyglucose F18
/
Traitement médicamenteux
/
Carcinome pulmonaire à petites cellules
/
Tomographie par émission de positons couplée à la tomodensitométrie
/
Poumon
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Nuclear Medicine and Molecular Imaging
Année:
2007
Type:
Article
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