Application of serum procalcitonin and high-sensitivity C-reactive protein in the early evaluation of inflammatory disease / 中国基层医药

ABSTRACT

Objective To explore the clinical applications of the PCT and hs-CRP in inflammatory diseases.Methods The sera of 79 infectious patients were randomly collected.54 samples were bacterial infectious patients,25 samples were nonbacterial infectious patients.The serum levels of PCT and hsCRP in 79 infectious cases were detected by immune fluorescence and Immunoturbidimetry respectively.Results The positive rate of PCT in bacterial infectious patients were much higher than that in nonbacterial infectious patients (x2 =48.337,P ＜ 0.01),and the sensitivity was 92.5％,the specificity was 88.0％ ;The positive rate of hs-CRP in bacterial infectious patients were much higher than that in nonbacterial infectious patients (x2 =22.347,P ＜ 0.01),and the specificity was 88.9％,the specificity was 56.0％.The positive predictive value (88.9％) and negative predictive value (70.0％) of hs-CRP were lower than those of PCT (positive predictive values of 94.3％ and negative predictive value of 84.6％).Conclusion Theserum levels of PCT in inflammatory diseases were significantly increased with an high sensitivity and high specificity.Thus,it may be used as a new marker of inflammatory,which can be helpful in the early evaluation of infectious disease and the observation of curative efficacy.