Determination of Residual Organic Solvents in Dimemorfan Phosphate by GC / 中国药师
China Pharmacist
; (12): 563-565, 2014.
Article
de Zh
| WPRIM
| ID: wpr-448071
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WPRO
ABSTRACT
Objective:To determine the content of chloroform, ethyl acetate and DMF in dimemorfan phosphate by gas chromatog-raphy (GC). Methods:The capillary gas chromatography was used with a PEG-20M column, programmed temperature, water as the solvent and FID as the detector. Results:The three organic solvents were separated and showed good linear relationship (r>0. 999 0). The detection limit of chloroform, ethyl acetate and DMF was 0. 63,0. 60 and 8. 92μg·ml-1 , respectively. The residues of the organ-ic solvents in three batches of the samples all met with the requirements of ICH. Conclusion: The method is sensitive, accurate and reliable, and can be used in the quality control of dimemorfan phosphate.
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WPRIM
langue:
Zh
Texte intégral:
China Pharmacist
Année:
2014
Type:
Article