Effects of Antipsychotics on the Inflammatory Response System of Patients with Schizophrenia in Peripheral Blood Mononuclear Cell Cultures
Clinical Psychopharmacology and Neuroscience
;
: 144-151, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-44837
ABSTRACT
OBJECTIVE:
We investigated the effects of antipsychotics on immune-challenged peripheral blood mononuclear cell (PBMC) cultures.METHODS:
Blood samples were collected from twelve patients with first-episode schizophrenia. The PBMCs were separated and cultures were prepared and stimulated with lipopolysaccharide (LPS) or polyinosinicpolycytidylic acid (poly[IC]), and then separately treated with a typical antipsychotic (haloperidol) or atypical antipsychotic (clozapine, quetiapine, or risperidone). Pro-inflammatory (interferon gamma [IFN-gamma]) and anti-inflammatory (interleukin [IL]-4 and IL-10) cytokine levels were measured in the LPS- or poly(IC)-stimulated PBMC cultures treated with antipsychotics.RESULTS:
Haloperidol and quetiapine significantly increased the IL-4 levels (p<0.05) in LPS-stimulated PBMC cultures, while clozapine and quetiapine significantly enhanced the IL-4 levels (p<0.05) in poly(IC)-stimulated PBMC cultures. Only treatment with haloperidol resulted in a significant increase in IL-10 production (p<0.05) in LPS-stimulated PBMC cultures, whereas clozapine, quetiapine, and risperidone treatment significantly increased IL-10 production (p<0.05) in poly(IC)-stimulated PBMC cultures. All of the antipsychotics reduced the IFN-gamma level significantly (p<0.05) in LPS- and poly(IC)-stimulated PBMC cultures.CONCLUSION:
Antipsychotic treatment altered immune function by raising the levels of anti-inflammatory cytokines (IL-4 and IL-10) and suppressing the levels of pro-inflammatory cytokines (IFN-gamma).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Schizophrénie
/
Neuroleptiques
/
Lipopolysaccharides
/
Cytokines
/
Interleukine-4
/
Interleukine-10
/
Clozapine
/
Rispéridone
/
Techniques de culture cellulaire
/
Fumarate de quétiapine
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Clinical Psychopharmacology and Neuroscience
Année:
2013
Type:
Article
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