The expression of clusterin and P-glycoprotein in hepatic cell carcinoma and its relationship / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
;
(36): 59-61, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-450571
ABSTRACT
Objective To study the expression of clusterin (CLU) and P-glycoprotein (P-gp) in hepatic cell carcinoma (HCC) and its relationship.Methods The expression of CLU gene in the tissue of H CC (41 cases),cirrhosis(10 cases) and normal liver (10 cases) and the expression of P-gp in the tissue of HCC were detected by immunohistochemical method.Results The positive expression rate of CLU was 82.93%(34/41) in HCC,and negative or weak positive were detected in cirrhosis and normal liver tissue.The positive expression rate of CLU was significantly correlated with Edmondson's histological grade (P < 0.05),but had no correlation with patients' age,sex and cirrhosis (P > 0.05).The positive expression rate of P-gp in HCC was 70.73%(29/41).There was significant correlation between the expression of CLU and P-gp (P < 0.05).Conclusions The over expression of CLU is significantly associated with clinical multidrug resistance in HCC.It should be a potential target for treatment of HCC.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Postgraduates of Medicine
Année:
2014
Type:
Article
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