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Frequency of Bone Marrow Toxicity by Using Pattern of Azathioprine in Inflammatory Bowel Disease Patients
Intestinal Research ; : 244-250, 2012.
Article Dans Coréen | WPRIM | ID: wpr-45087
ABSTRACT
BACKGROUND/

AIMS:

The most important adverse effect of azathioprine (AZA) is bone marrow toxicity (BMT). Many physicians have preferred a gradual dose increment (GDI) policy for the prevention of BMT. The aim of this study was to evaluate the efficacy of GDI for the prevention of AZA-induced BMT in inflammatory bowel disease (IBD) patients.

METHODS:

The medical records of IBD patients who received AZA in 6 university hospitals were reviewed. The patients were divided into two groups the GDI group (initial dose or =2 mg/kg).

RESULTS:

A total of 308 patients were enrolled (male to female ratio, 12.3; mean age, 34.91+/-14.19 years; ulcerative colitis, 43.5%; Crohn's disease, 55.2%; and intermediate colitis, 1.3%). The overall incidence of BMT was 16.2% (50/308). BMT developed most frequently between fourth to eighth week (26%, 13/50). The rate of BMT of the non-GDI group was significantly higher than that of the GDI group (27.5%, 11/40 vs. 14.6%, 39/268, P=0.038). A multivariate analysis showed that the only factor related to BMT was a non-GDI policy (P=0.036; odds ratio, 2.41; 95% confidence interval, 1.06-5.49).

CONCLUSIONS:

A GDI policy could be useful for reducing AZA-induced BMT in Korean IBD patients.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Azathioprine / Moelle osseuse / Maladies inflammatoires intestinales / Rectocolite hémorragique / Maladie de Crohn / Odds ratio / Dossiers médicaux / Incidence / Analyse multifactorielle / Colite Type d'étude: Etude d'étiologie / Etude d'incidence / Étude pronostique Limites du sujet: Femelle / Humains langue: Coréen Texte intégral: Intestinal Research Année: 2012 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Azathioprine / Moelle osseuse / Maladies inflammatoires intestinales / Rectocolite hémorragique / Maladie de Crohn / Odds ratio / Dossiers médicaux / Incidence / Analyse multifactorielle / Colite Type d'étude: Etude d'étiologie / Etude d'incidence / Étude pronostique Limites du sujet: Femelle / Humains langue: Coréen Texte intégral: Intestinal Research Année: 2012 Type: Article