Progress of HGK research on tumors / 中国肿瘤临床

ABSTRACT

HGK is a germinal center kinase (GCK)-Ⅳand is involved in controlling cellular processes, such as cell motility, cy-toskeleton rearrangement, and cell proliferation. HGK is involved in a very complex network of signaling pathways and interactions in-volved in diseases, such as diabetes or cancer. HGK was determined to be highly overexpressed in different types of cancers, such as ovarian cancer, hepatocellular carcinoma, lung cancer, pancreatic cancer, and prostate cancer. Recent findings have shown that HGK is a novel target that may provide insight into new therapies to prevent or even treat many metabolic diseases, such as diabetes or even co-lon cancer, prostate cancer, breast cancer, ovarian cancer, pancreatic cancer, or hepatic cancer.