Comparison of the efects of compound s alvia miltiorrhiza pli l and salviami ltiorrhiza pill on platelet activation in hematoplasma in patients with coronary atherosclerosis / 中国医师杂志

ABSTRACT

Objective To compare the effects of compound salvia miltiorrhiza pill and salvia milti-orrhiza pill on platelet activation in hematoplasma in patients with coronary atherosclerosis , and guide clini-cal medication .Methods Ninety cases suffered coronary atherosclerosis who were treated with compound salvia miltiorrhiza, salvia miltiorrhiza and palcebo for two months course of treatment were divided into com-pound salvia miltiorrhiza , salvia miltiorrhiza and control groups , Normal group included 30 physical fitness were treated with placebo.Contents of PTGIS mRNA, cAMP, TXA2 and PGI2 in hematoplasma were treated with palcebo.Contents of PTGIS mRNA, cAMP, TXA2 and PGI2 in hematoplasma were detected by real-time RT-PCR and radioimmunoassay , respectively.Res ults In coronary atherosclerosis groups , cAMP, TXA2 ., PTGIS mRNA were decreased markedly , TXA2 were increased markedly. Compund salvia miltior-rhiza and salvia miltiorrhiza could increase the expression of cAMP , PGI2 and PTGIS mRNA but TXA2 , the content of TXA2 .in compund salvia miltiorrhza and salvia miltiorrhiza groups were decreased .Conclusion Compound salvia miltiorrhiza and salvia miltiorrhiza can inhibit plateled activation .The effect on inhibi-ting platelet activation of compound salvia miltiorrhiza is better than salvia miltiorrhiza .